a) Protection of 1-Phenylethanol by 3,4-Dihydro-2H-pyran
b) Purification of 2-(1-Phenylethoxy)-tetrahydro-2H-pyran by Flash Column Chromatography
Starting material (1-Phenylethanol)
1-Phenylethanol with 3,4-Dihydro-2H-pyran and anhydrous ether in cold bath with calcium chloride guard tube.
Toluenesulfonic acid monohydrate added and stirring with magnetic stirrer.
TLC with hexane:ethyl acetate (4:1) solvent system to confirm convertion
Washing of organic layer with saturated sodium bicarbonate solution followed by saturated sodium chloride solution.
Remove the solvents using the rotary evaporator
Flash Column Chromatography
See also: CM2121 Expt 2
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