Thursday, October 11, 2007

CM2121 Expt 2

CM2121 Expt 2
a) Protection of 1-Phenylethanol by 3,4-Dihydro-2H-pyran
b) Purification of 2-(1-Phenylethoxy)-tetrahydro-2H-pyran by Flash Column Chromatography


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Starting material (1-Phenylethanol)

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1-Phenylethanol with 3,4-Dihydro-2H-pyran and anhydrous ether in cold bath with calcium chloride guard tube.

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Toluenesulfonic acid monohydrate added and stirring with magnetic stirrer.

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TLC with hexane:ethyl acetate (4:1) solvent system to confirm convertion

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Washing of organic layer with saturated sodium bicarbonate solution followed by saturated sodium chloride solution.

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Remove the solvents using the rotary evaporator

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Flash Column Chromatography

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See also: CM2121 Expt 2

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